Ryan Merkow, MD, MS

Ryan Merkow, MD, MS, is a board-certified surgical oncologist with a clinical practice that focuses on treating complex gastrointestinal cancers, including metastatic cancers that have spread to the liver. Dr. Merkow is an expert in liver, bile duct, pancreas, stomach, small bowel, appendix, neuroendocrine and peritoneal surface cancers. He specializes in patient-centered treatment options for complex cancers, allowing the delivery of comprehensive care that is customized to each patient’s individual needs and healthcare goals.

In order to provide his patients with the best solution(s), Dr. Merkow offers both nonsurgical and surgical options. His treatments include regional cancer therapies, such as hepatic artery infusion (HAI) pump chemotherapy, a technique that supplies high doses of chemotherapy directly to the liver. This therapy is used to kill any remaining cancer cells after visible tumors have been surgically removed, as well as to convert someone from unresectable (all tumors cannot be removed) to resectable (all tumors are able to be cleared from the liver). He also provides other liver directed therapies, such as ablation, designed to selectively target liver tumors without injuring nearby healthy tissue.

In addition to regional therapies, Dr. Merkow performs minimally invasive and robotic surgery to treat cancer, offering accuracy and precision while removing life-threatening tumors. This allows his patients to recovery faster with less pain and scarring so they can get back to their daily lives sooner.

Along with his dedication to his clinical practice, Dr. Merkow is passionate about advancing treatment through clinical research and making surgery and cancer care delivery safer, more efficient and patient-centered. His research focuses primarily on surgical outcomes, quality improvement and patient safety, which has been published in over 150 peer-reviewed articles in highly respected, medical journals, like the Journal of the American Medical Association (JAMA), Journal of the National Cancer Institute (JNCI), British Journal of Quality and Patient Safety, Annals of Surgery, Annals of Surgical Oncology and more. With his research expertise, Dr. Merkow will join the University of Chicago’s Health Services Research Center.

Dr. Merkow is active, and has held leadership roles, in several national healthcare organizations, including serving as chair of the Association for Academic Surgery Clinical and Health Services Research Committee. Additionally, with healthcare constantly evolving, he provides clinical training to medical students, residents and fellows, mentoring them as they embark on their medical careers.