
Jay Khambhati, MD
Jay Khambhati, MD
Assistant Professor of Medicine
Specialties
- Interventional Cardiology
- Cardiology (Heart Care)
Locations
- Chicago - Hyde Park
- Crown Point, IN - Virginia Street
Jay Khambhati, MD, is an interventional cardiologist who specializes in catheter-based management and treatments for patients with structural heart disease and complex coronary artery disease.
With a passion for advancing heart care, Dr. Khambhati is committed to delivering an approach to care that combines the latest medical innovations with a deep understanding of each patient’s unique needs. Dr. Khambhati’s expertise and experience allow him to develop personalized and effective treatment plans for his patients, which includes performing:
- Transcatheter aortic valve replacement
- Transcatheter mitral valve replacement and edge to edge repair
- Transcatheter tricuspid valve replacement and edge to edge repair
- Patent foramen ovale and atrial septal defect closure
- Paravalvular leak closure
- Left atrial appendage closure
- Balloon valvuloplasty
- Percutaneous coronary intervention
- Alcohol Septal Ablation
In addition to his clinical practice, Dr. Khambhati is actively researching new methods and techniques designed to improve care for his patients. Through his research, Dr. Khambhati investigates the durability of transcatheter aortic valves, the rate of progression of aortic valve stenosis, hypoattenuating leaflet thickening (HALT) after TAVR, and the use of intravascular imaging and calcium modification in acute coronary syndromes. Dr. Khambhati has also worked on machine learning models to detect the presence and severity of regurgitant valve lesions in echocardiography. He has served as a co-investigator on large multicenter clinical trials investigating novel therapies in interventional cardiology.