UChicago Medicine Comprehensive Cancer Center

CAR T-cell therapy is a multi-step process that takes place over several weeks. Treatment may occur in the hospital or on an outpatient basis, which allows patients to return to the comfort of their home or nearby accommodations during the treatment process. The CAR T-cell therapy process includes the following:

  • Collecting the T cells. T cells are collected through apheresis. This simple, non-invasive process removes the T cells from the blood (similar to the method for blood donation) and returns the remaining blood back into the body.
  • Supercharging the T cells. Scientists in a laboratory insert an antibody-like protein called a chimeric antigen receptor (CAR) on the surface of the T cells.
  • Multiplying the CAR T cells. CAR T cells multiply in the lab until they number in the millions. The cells are then frozen and returned to the patient’s hospital.
  • Infusing the CAR T cells. Most patients undergo a brief course of chemotherapy. When the CAR T cells are returned to the patient’s bloodstream, they continue to multiply. They now act as “attacker” cells: seeking out, recognizing and destroying cancer cells that have the targeted antigen on their surface.
  • After CAR T-cell therapy. Patients stay in the hospital for a minimum of two weeks for monitoring and treatment of side effects, including potential adverse events. CAR T cells can remain active in the body and continue to safeguard the patient against recurrence of the cancer, bringing long-term remission.

 

CAR T-cell therapy infographic
Download an Infographic About How CAR T-cell Therapy Works (PDF)

Convenient Locations for Cancer Care

Request an Appointment for CAR T-Cell Therapy

We are currently experiencing a high volume of inquiries, leading to delayed response times. For faster assistance, please call 1-855-702-8222 to schedule your appointment.

If you have symptoms of an urgent nature, please call your doctor or go to the emergency room immediately.

For Referring Physicians

To refer a patient for CAR T-cell therapy, please call 1-844-482-7823.

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By submitting this form you acknowledge the risk of sending this information by email and agree not to hold the University of Chicago or University of Chicago Medical Center liable for any damages you may incur as a result of the transfer or use of this information. The use or transmittal of this form does not create a physician-contact relationship. More information regarding the confidentiality of this request can be found in our Privacy Policy.