Clinical Trials at Ingalls Memorial
Our goal is to provide the highest level of care to all of our patients, and that includes offering novel treatments before they are widely available. If you are a cancer patient, you may be eligible for one of our current clinical trials.
Anal Cancer
- Stage IV
- A Randomized Phase III Study of Immune Checkpoint Inhibition with Chemotherapy in Treatment-Naïve Metastatic Anal Cancer Patients
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Bile Duct Cancer
- Phase 2/3 Randomized, Controlled Study of CTX-009 in Combination with Paclitaxel vs Paclitaxel Alone in Adult Pts with Unresectable Advanced, Metastatic or Recurrent Biliary Tract Cancers who have received 1 Prior Systemic Chemotherapy Regimen CTX-009-002
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Phase III Randomized Controlled Global Multicenter Study to Evaluate the Efficacy and Safety of Oral Tinengotinib vs Physician’s Choice in Subjects with FGFR-altered, Chemotherapy and FGFR Inhibitor-Refractory/Relapsed Cholangiocarcinoma (FIRST-308)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Bladder Cancer
- Stage II or Stage III
- A Phase II Study of Gemcitabine Plus Cisplatin Chemotherapy in Patients with Muscle-Invasive Bladder Cancer with Bladder Preservation for Those Patients Whose Tumors Harbor Deleterious DNA Damage Response (DDR) Gene Alterations
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase 2 Multi-Cohort, Open-Label, Multi-Center Clinical Study Evaluating the Efficacy and Safety of Disitamab Vedotin (RC48-ADC) in Subjects with HER2-Expressing Locally-Advanced Unresectable or Metastatic Urothelial Carcinoma
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Breast Cancer
- Stage I-IIIC
- The COMPASSHER2 Trials (COMprehensive Use of Pathologic Response ASSessment to Optimize Therapy in HER2-Positive Breast Cancer): COMPASSHER2 Residual Disease (RD), A Double-Blinded, Phase III Randomized Trial of T-DM1 Compared with T-DM1 and Tucatinib
- If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
- Stage I-III
- Optimizing Endocrine Therapy through Motivational Interviewing and Text Interventions
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage II-III
- OptimICE-PCR: De-Escalation of Therapy in Early-Stage TNBC Patients Who Achieve pCR After Neoadjuvant Chemotherapy with Checkpoint Inhibitor Therapy
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IIIA
- A Randomized Phase III Clinical Trial Evaluating Post-Mastectomy Chest Wall and Regional Nodal XRT and Post-Lumpectomy Regional Nodal XRT in Patients with Positive Axillary Nodes Before Neoadjuvant Chemotherapy Who Convert to Pathologically Negative Axillary Nodes After Neoadjuvant Chemotherapy
- If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
- Stage T2 - IIIC
- Randomized Phase III Trial of Adjuvant Therapy Comparing Doxorubicin Plus Cyclophosphamide Followed by Weekly Paclitaxel with or without Carboplatin for Node-Positive or High-Risk Node-Negative Triple-Negative Invasive Breast Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV
- A Randomized, Double-Blind, Phase III Trial of Paclitaxel / Trastuzumab / Pertuzumab with Atezolizumab or Placebo in First-Line HER2-Positive Metastatic Breast Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Early Stage
- Phase III Adjuvant Trial Evaluating the Addition of Adjuvant Chemotherapy to Ovarian Function Suppression plus Endocrine Therapy in Premenopausal Patients with pN0-1, ER-Positive/HER2-Negative Breast Cancer and an Oncotype Recurrence Score ≤ 25 (OFSET)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IB-IIIC
- A Randomized, Phase III Trial to Evaluate the Efficacy and Safety of Pembrolizumab (MK-3475) as Adjuvant Therapy for Triple Receptor-Negative Breast Cancer with > 1 cm Residual Invasive Cancer or Positive Lymph Nodes (ypN1mi, ypN1-3) After Neoadjuvant Chemotherapy
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage — Stage 0-pTis
- Cluster Randomized Controlled Trial Patient and Provider Decision Support to Increase Chemoprevention Informed Choice Among Women with Atypical Hyperplasia or Lobular Carcinoma in Situ–Making Informed Choices on Incorporating Chemoprevention into Care MiCHOICE
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Shorter Anthracycline-Free Chemo Immunotherapy Adapted to Pathological Response in Early Triple Negative Breast Cancer (SCARLET), A Randomized Phase III Study
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV or Unresectable Stage III
- A Randomized, Placebo-Controlled, Double-Blind, Phase II Trial of Nanoparticle Albumin-bound Paclitaxel (nab-paclitaxel, Abraxane®) with or without Mifepristone for Advanced, Glucocorticoid Receptor-Positive, Triple-Negative Breast Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV
- Phase II Study of Pembrolizumab and Mifepristone in Patients with Advanced HER2-Negative Breast Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- The GLORIA Study: A Phase III, Randomized, Open-Label Study of the Anti-Globo H Vaccine Adagloxad Simolenin (OBI 822)/OBI 821 in the Adjuvant Treatment of Patients with High Risk Early Stage Globo H-Positive Triple Negative Breast Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV
- Title Randomized Phase II Study of Sacituzumab Govitecan with or without Pembrolizumab in PD-L1-Negative Metastatic Triple Negative Breast Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Innovative Combination Immunotherapy for Metastatic Triple Negative Breast Cancer (TNBC): A Multicenter, Multi-Arm Translational Breast Cancer Research Consortium Study
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage II or Stage III
- A Phase II Trial of Avelumab or Hydroxychloroquine with or without Palbociclib to Eliminate Dormant Breast Cancer (“PALAVY”)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Phase 1 Pilot Study with Dose Expansion of Chemotherapy in Combination with CD40 Agonist and Flt3 Ligand in Metastatic Triple Negative Breast Cancer (SCCC-03121)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage I-III
- A Phase II Circulating Tumor DNA Enriched, Genomically Directed Post-Neoadjuvant Trial for Patients with Residual Triple Negative Breast Cancer (PERSEVERE)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A First-in-Human Study of Mutant-selective PI3Ka Inhibitor, RLY-2608, as a Single Agent in Advanced Solid Tumor Patients and in Combination With Fulvestrant in Patients With Advanced Breast Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Stage I-III
CAMBRIA-1: A Phase III, Open-Label, Randomised Study to Assess the Efficacy and Safety of Extended Therapy with Camizestrant (AZD9833, a Next Generation, Oral Selective Estrogen Receptor Degrader) versus Standard Endocrine Therapy (Aromatase Inhibitor or Tamoxifen) in Patients with ER+/HER2- Early Breast Cancer and an Intermediate or High Risk of Recurrence Who Have Completed Definitive Locoregional Therapy and at Least 2 Years of Standard Adjuvant Endocrine-Based Therapy Without Disease Recurrence
If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
Colon/Rectal Cancer
- Stage II or III
- The Janus Rectal Cancer Trial: A Randomized Phase II/III Trial Testing the Efficacy of Triplet versus Doublet Chemotherapy Regarding Clinical Complete Response and Disease-Free Survival in Patients with Locally Advanced Rectal Cancer.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage II - III
- Duloxetine To Prevent Oxaliplatin-Induced Chemotherapy-Induced Peripheral Neuropathy: A Randomized, Double-Bind, Placebo-Controlled Phase II To Phase III Study
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage II or Stage III
- Colon Adjuvant Chemotherapy Based on Evaluation of Residual Disease (CIRCULATE-US)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Stage IV
An Open-Label, Multicenter, Randomized Phase 3 Study of First-Line Encorafenib Plus Cetuximab with or without Chemotherapy Versus Standard of Care Therapy with a Safety Lead-In of Encorafenib and Cetuximab Plus Chemotherapy in Participants with Metastatic BRAF V600E-Mutant Colorectal Cancer.
If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
- A Phase 1b/2 Study of VS-6766 and Cetuximab in Patients with Advanced KRAS Mutated Colorectal Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Gastric Cancer (Stomach Cancer)
- Randomized Phase III Trial of MFolfirinox +/- Nivolumab vs. Folfox +/- Nivolumab for First-Line Treatment of Metastatic HER2-Negative Gastroesophageal Adenocarcinoma
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IB - IIIC
- PERIOP-FOLFIRINOX: A Pilot Trial of Perioperative Genotype-Guided Irinotecan Dosing of gFOLFIRINOX for Locally Advanced Gastroesophageal Adenocarcinoma
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Gynecologic Cancer
- Stage III - IV
- A Randomized Placebo Controlled Phase II Trial of Metformin in Conjunction with Chemotherapy Followed by Metformin Maintenance Therapy in Advanced Stage Ovarian, Fallopian Tube and Primary Peritoneal Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Phase IB/II Multi-Cohort Study of Targeted Agents with Atezolizumab for Patients with Recurrent or Persistent Endometrial Cancer (AFT-50 - Endomap)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Phase 1/2 Study of REGN5668 (MUC16 X CD28, a Costimulatory Bispecific) Administered in Combination with Cemplumab or REGN4018 (MUC16 X CD3)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- GoG-3078 Randomized, Multicenter, Open-Label, Phase 3 Study of Mirvetuximab Soravtansine in Combination with Bevacizumab versus Bevacizumab Alone as Maintenance Therapy for Patients with FRα-Positive Recurrent Platinum-Sensitive Epithelial Ovarian, Fallopian Tube, or Primary Peritoneal Cancers Who Have Not Progressed after Second Line Platinum-Based Chemotherapy Plus Bevacizumab.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase 1b/2 Basket Study of ACR-368 as Monotherapy and in Combination with Gemcitabine in Adult Subjects with Platinum-Resistant Ovarian Carcinoma, Endometrial Adenocarcinoma, and Urothelial Carcinoma Based on Acrivon OncoSignature® Status.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Head and Neck Cancer
- Randomized Phase 2 Study of Nivolumab and Ipilimumab with or without Cabozantinib in Patients with Advanced Nasopharyngeal Carcinoma that have Progressed after Platinum Treatment and Immunotherapy.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase II/III Trial of Chemotherapy + Cetuximab vs Chemotherapy + Bevacizumab vs Atezolizumab + Bevacizumab Following Progression on Immune Checkpoint Inhibition in Recurrent/Metastatic Head and Neck Cancers
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage - varies
- Randomized Phase II/III Trial of Radiation with High-Dose Cisplatin (100 mg/m2) Every Three Weeks versus Radiation with Low-Dose Weekly Cisplatin (40 mg/m2) for Patients with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (SCCHN)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- TARGET HPV: A Randomized Phase I/II Trial of TheraT® Vectors Expressing HPV16 Specific Antigens in Combination with Neoadjuvant Chemotherapy followed by Transoral Robotic Surgery or Risk/Response Stratified Chemoradiotherapy for Locoregional HPV16+ Oropharyngeal Cancer.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase II Study of Pembrolizumab in Combination with Circulating Tumor DNA Response-Adaptive Pulsed Chemotherapy in Recurrent/Metastatic Head and Neck Squamous Cell Carcinoma: The SINERGY trial (Squamous cell carcInoma of head and NEck Response-Guided therapY)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase II Study of Adjuvant Ado-Trastuzumab Emtansine (T-DM1) in HER2-Positive Salivary Gland Carcinomas.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage III-IV
- Pilot Study of Induction Therapy Followed by Response-Adaptive Treatment and Dynamic Changes in Circulating Tumor DNA in Locoregionally Advanced HPV Negative Head and Neck Squamous Cell Carcinoma
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage III-IV
- A Phase I Study of Xevinapant with Radiation and Concurrent carboplatin and Paclitaxel in Patients Ineligible for Cisplatin with Locoregionally Advanced Squamous Cell Carcinoma of the Head and Neck (The EXtRaCT Study).
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Leukemia
- Any Newly Diagnosed
- Connect® Myeloid: The Myelofibrosis (MF), Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Disease Registry
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage I - IV
- Randomized, Phase III Study of Early Intervention with Venetoclax and Obinutuzumab Versus Delayed Therapy with Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients with Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL): EVOLVE CLL/SLL Study
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Liver Cancer
A Phase 2, Randomized Study to Evaluate the Optimized Dose, Safety, and Efficacy of Livmoniplimab in Combination with Budigalimab for Locally Advanced or Metastatic Hepatocellular Carcinoma (HCC) Patients who Have Progressed After an Immune Checkpoint Inhibitor Containing Regimen in First-Line HCC – LIVIGNO-1.
If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
A Phase 1/2 Exploratory Study of the TBL1 Inhibitor, Tegavivint (BC2059), in Patients with Advanced Hepatocellular Carcinoma (ITER-002-HCC)
If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
BCLC Stage B or C
Locally Advanced or Metastatic Hepatocellular Carcinoma: Dose Optimization, Safety, and Efficacy of Livmoniplimab in Combination with Budigalimab in Subjects Who Have Not Previously Received Systemic Treatment – LIVIGNO-2.
If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
Lung Cancer
- Stage IIIB-IV
- Study Title A Phase 1B Study of Venetoclax in Combination with Pembrolizumab in Subjects with Previously Untreated Non-Small Cell Lung Cancer Whose Tumors have High PD-L1 Expression
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IIIB-C or Stage IV
- A Randomized Phase II/III Trial of Modern Immunotherapy Based Systemic Therapy With or Without SBRT for PD-L1-Negative, Advanced Non-Small Cell Lung Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV
- Randomized Phase 3 Study of Combination AZD9291 (Osimertinib) and Bevacizumab versus AZD9291 (Osimertinib) Alone as First-Line Treatment for Patients with Metastatic EGFR-Mutant Lung Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV
- Master Protocol to Evaluate Biomarker-Drive Therapies and Immunotherapies in Previously-Treated Non-Small Cell Lung Cancer (Lung-MAP Screening Study)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV or recurrent disease
- Phase II Study of Sotorasib (AMG 510) in Participants with Previously Treated Stage IV or Recurrent KRAS G12C Mutated Non-Squamous Non-Small Cell Lung Cancer (ECOG-ACRIN LUNG-MAP Sub-Study)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV or Recurrent
- PRAGMATICA - LUNG: A Prospective Randomized Study of Ramucirumab (LY3009806; NSC 749128) Plus Pembrolizumab Versus Standard of Care for Participants Previously Treated with Immunotherapy for Stage IV or Recurrent Non-Small Cell Lung Cancer.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage I-II
- Phase III Randomized Placebo-Controlled Double-Blind Multi-Center International Study of Durvalumab with Stereotactic Body Radiation Therapy for the Treatment of Patients with Unresected Stage I/II, Lymph-Node Negative Non-Small Cell Lung Cancer (PACIFIC-4/RTOG-3515)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase II Trial of Durvalumab (MEDI4736) and Ablative Radiation in Extensive-Stage Small Cell Lung Cancer (DARES)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase 2, Multicenter, Randomized, Open-Label Study of DS-7300A, A B7-H3 Antibody Drug Conjugate (ADC), in Subjects with Pretreated Extensive-Stage Small Cell Lung Cancer (ES-SCLC)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage I-III
- A Randomized, Double-blind, Placebo-controlled Phase 3 Study of Pembrolizumab (MK-3475) in Combination with Concurrent Chemoradiation Therapy Followed by Pembrolizumab with or without Olaparib (MK-7339), Compared to Concurrent Chemoradiation Therapy Alone in Participants with Newly Diagnosed Treatment-Naïve Limited-Stage Small Cell Lung Cancer (LS-SCLC)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage III
- Open-label Phase 3 Study of MK-7684A (Coformulation of Vibostolimab with Pembrolizumab) in Combination with Concurrent Chemoradiotherapy followed by MK- 7684A Versus Concurrent Chemoradiotherapy followed by Durvalumab in Participants with Unresectable, Locally Advanced, Stage III Non-Small Cell Lung Cancer (KEYVIBE-006): MK-7684A 006-00.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
A Phase 1/2 Study of the Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor NVL-655 in Patients with Advanced NSCLC and Other Solid Tumors (ALKOVE-1).
If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
Lymphoma
- Stage I - IV
- Randomized, Phase III Study of Early Intervention with Venetoclax and Obinutuzumab Versus Delayed Therapy with Venetoclax and Obinutuzumab in Newly Diagnosed Asymptomatic High-Risk Patients with Chronic Lymphocytic Leukemia (CLL)/Small Lymphocytic Lymphoma (SLL): EVOLVE CLL/SLL Study
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Phase 1b/2 Trial of Hu5F9-G4 in Combination with Rituximab or Rituximab + Chemotherapy in Patients with Relapsed/Refractory B-cell Non-Hodgkin’s Lymphoma
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage varies
- Phase II Study of Pembrolizumab in Combination with R-CHOP for Patients with Untreated, High-Risk, Non-Germinal Center-Derived DLBCL
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase 1b/3 Double-Blind, Randomized, Active-Controlled, 3-Stage, Biomarker Adaptive Study of Tazemetostat or Placebo in Combination with Lenalidomide Plus Rituximab in Subjects with Relapsed/Refractory Follicular Lymphoma
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase I/II Study of Acalabrutinib, Venetoclax and Obinutuzimab in Patients with Relapsed/Refractory and Previously Untreated Mantle Cell Lymphoma
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Myelodysplastic Syndrome (MDS)
- Stage – not applicable
- Connect® Myeloid: The Myelofibrosis (MF), Myelodysplastic Syndromes (MDS) and Acute Myeloid Leukemia (AML) Disease Registry
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Multiple Myeloma
- High-Risk SMM
- Daratumumab to Enhance Therapeutic Effectiveness of Revlimid in Smoldering Myeloma (DETER-SMM)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Open-label, Single-arm, Phase 2 Study of Initial Treatment with Daratumumab (Darzalex), Carfilzomib (Kyprolis), Lenalidomide (Revlimid) and Low Dose Dexamethasone (DKRd) in Newly Diagnosed, Multiple Myeloma Requiring Systemic Chemotherapy
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase II Study of Belantamab Mafodotin in Combination with Carfilzomib, Pomalidomide, and Dexamethasone (KPd) in Patients with Relapsed Multiple Myeloma
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Neuroendocrine Tumors
- Stage IV
- A Randomized Phase II/III Trial of First Line Platinum/ Etoposide with or without Atezolizumab in Patients with Poorly Differentiated Extrapulmonary Small Cell Neuroendocrine Carcinomas
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Ovarian Cancer
- Stage III - IV
- A Randomized Placebo Controlled Phase II Trial of Metformin in Conjunction with Chemotherapy Followed by Metformin Maintenance Therapy in Advanced Stage Ovarian, Fallopian Tube and Primary Peritoneal Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV
- A Phase II Trial of Pembrolizumab and Lenvatinib in Patients with Recurrent or Persistent Clear Cell Carcinoma of the Ovary
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Pancreas Cancer
- Creon® (pancrelipase) therapy for subjects with exocrine pancreatic insufficiency (EPI) due to pancreatic cancer: A double-blind, randomized, parallel design with 2 dose cohorts of pancrelipase in resected pancreatic cancer subjects and an open-label single dose cohort in non-resected pancreatic cancer subjects
- If you are eligible and would like to participate, please contact the research staff at 708-915-4673 (HOPE).
- Comparing the Clinical Impact of Pancreatic Cyst Surveillance Programs
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage IV
- A Phase 1b/2a Study of Gemcitabine and Nab-paclitaxel in Combination with Avutometinib (VS-6766) and Defactinib in Patients with Previously Untreated Metastatic Adenocarcinoma of the Pancreas
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Prostate Cancer
- Phase II Multi-Dose Multi-Arm Parallel Assignment Study to Evaluate Safety, Tolerability and Preliminary Efficacy of XmAb®20717 Alone or in Combination with Chemo or Targeted Therapies in Selected Patients with Metastatic Castration-Resistant Prostate Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Randomized Phase II Trial of Neoadjuvant Enzalutamide Plus the Glucocorticoid Receptor Antagonist Relacorilant Versus Placebo for Patients with High-Risk Localized Prostate Cancer
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- ProsGATE: Geriatric Assessment and Technology Evaluation in Prostate cancer.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
Solid Tumors and Multiple Disease Sites
- Molecular Analysis for Combination Therapy Choice (ComboMATCH).
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Locally Advanced / Stage IV
- Phase 1b Dose‑Escalation Study of Cabozantinib (XL184) Administered Alone or in Combination with Atezolizumab to Subjects with Locally Advanced or Metastatic Solid Tumors
- If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
- Stage IV
- A Randomized Study Investigating the Pharmacokinetics of Standard Interval Dosing Compared to Extended Interval Dosing of Nivolumab or Pembrolizumab in Locally Advanced or Metastatic Cancers
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Stage III or Stage IV
- An Open-Label, Multicenter, First-in-Human, Dose-Escalation, Phase 1 Study of INBRX-106 in Subjects with Locally Advanced or Metastatic Solid Tumors
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase 1 Study of ZN-c3 as a Single Agent in Subjects with Solid Tumors
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- Phase I/IIa Open Label, Multicenter Study to Assess the Safety, Tolerability, Pharmacokinetics, and Efficacy of AFM24 in Combination with Atezolizumab in Patients with Selected Advanced/Metastatic EGFR-Expressing Cancers.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
- A Phase I Study of Oral LOXO-260 in Patients with RET Fusion-Positive Solid Tumors, Medullary Thyroid Cancer, and Other Tumors with RET Activation Refractory to Selective RET Inhibitors.
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
A Phase 1/2a, Multicenter, Open-Label, First in Human Study to Assess the Safety, Tolerability, Pharmacokinetics, and Preliminary Antitumor Activity of DB-1303/BNT323 in Patients with Advanced/Metastatic Solid Tumors (DB-1303-O-1001).
If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
Study Title An Open-Label, Multicenter Study of LOXO-435 (LY3866288) in Advanced Solid Tumor Malignancies with FGFR3 Alterations.
If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
- Stage IV
- ART0380C004. A Phase II, Open-label, Multi-center, Basket Study of the ATR Kinase Inhibitor ART0380 Administered Orally as Monotherapy to Patients with Biologically Selected Advanced or Metastatic Solid Tumors (ARTIST)
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673).
A Phase 1/2 Study of the Selective Anaplastic Lymphoma Kinase (ALK) Inhibitor NVL-655 in Patients with Advanced NSCLC and Other Solid Tumors (ALKOVE-1).
If you are eligible and would like to participate, please contact the research staff at 708-915-HOPE (4673).
Supportive Care
- Advanced Stage
- Randomized Phase III Trial of Olanzapine Versus Megestrol Acetate for Cancer-Associated Anorexia
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673) or send an email to clinicaltrials@ingalls.org.
Biobanking
- Protocol for Lymphoma Program Biobank
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673) or send an email to clinicaltrials@ingalls.org.
- Any Stage
- Genomic Analysis to Identify Correlates of the Inflamed Tumor-Phenotype in Patients with Advanced Malignancies Receiving Immunotherapy
- If you would like to learn more about this study, please contact the research staff at 708-915-HOPE (4673) or send an email to clinicaltrials@ingalls.org.