Gender
All
Age Group
18 Years and up
Accepting Healthy Volunteers
No
Inclusion Criteria:
- Histopathological or cytologically confirmed locally advanced or metastatic cancer
that meets protocol-defined criteria
- Disease that is not amenable to curative therapy, with prior therapies defined by
specific tumor types
- Contraceptive use by women and men should be consistent with local regulations
regarding the methods of contraception for those participating in clinical studies
- Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1
- Presence of measurable disease by RECIST, v1.1 assessed within 28 days prior to
start of first study intervention
- Anticipated life expectancy of at least 3 months
Exclusion Criteria:
- Females who are pregnant or breastfeeding
- Evidence of inadequate organ function
- Clinically significant cardiovascular disease
- Known active central nervous system (CNS) involvement by malignancy
- Non-malignant CNS disease such as stroke, epilepsy, CNS vasculitis, or
neurodegenerative disease or receipt of medications for these conditions within 2
years prior to study enrollment
- Active bacterial, fungal, or viral infections
- Prior receipt of chimeric antigen receptor (CAR) T-cell therapy, other cellular
therapy, or a FATE investigational human induced pluripotent stem cell (iPSC)
product
- History of (non-infectious) interstitial lung disease (ILD)/pneumonitis that
required steroids, current ILD/pneumonitis, or suspected ILD/pneumonitis that cannot
be ruled out based on imaging at screening
- Any history of Grade ≥3 immune-related AE or Grade ≥2 eye toxicity attributed to
prior cancer immunotherapy, other than endocrinopathy managed with replacement
therapy or asymptomatic elevation of serum amylase or lipase
- Active or history of autoimmune disease or immune deficiency
- Receipt of an allograft organ transplant