MRI Screening in Men at High Risk of Developing Prostate Cancer

  • Interventional
  • Recruiting
  • NCT05608694
Eligibility Details Visit Clinicaltrials.gov

MRI Screening in Men at High Risk of Developing Prostate Cancer

The purpose of this study is to determine whether or not Magnetic Resonance Images (MRI) will identify high-grade cancers earlier and more frequently in men at high risk of developing prostate cancer.

In this study the study team hypothesizes MR images will identify high-grade cancers earlier and more frequently in men at high risk of developing prostate cancer. Subjects will receive gadolinium (intravenous contrast agent) as part of their research MRI exam. While the deposition of gadolinium (Gd) has been demonstrated in numerous studies, the clinical consequences of Gd deposition are unknown. Gd enhanced MRI scans provide crucial medical information regarding prostate and prostate cancer imaging and contrast-enhanced images are a component of all guidelines and the PIRADS scoring system. The study team will compare baseline prostate MR images of men at high risk of developing prostate cancer to those without an identifiable predisposition and evaluate the role of a GRS in screening men with at elevated risk of being diagnosed with prostate cancer.

Gender
Male

Age Group
18 Years and up

Accepting Healthy Volunteers?
No

Inclusion Criteria:

         - Male age 18 and older

         - No known history of prostate cancer

         - No previous prostate resection or ablation (e.g. TURP, photovaporization)

        Exclusion Criteria:

         - Unable to tolerate MRI due to metal fragments or claustrophobia

         - Lack of a rectum

         - Hip arthroplasty

         - Prostate biopsy done within last 3 years

         - Prostate MRI done within last 3 years

At a Glance

National Government IDNCT05608694

IRB#IRB20-0038

Lead SponsorUniversity of Chicago

Lead PhysicianScott E. Eggener

Collaborator(s)N/A

EligibilityMale
18 Years and up
Recruiting